Whether you are practicing evidence-informed decision making or conducting research (e.g. a systematic review), the first step of the process is to clearly define the question or problem in a searchable and answerable format. This step of the process helps you answer the questions:
Source: NCCMT.
Using a framework to develop your question can help to identify the main concepts of your review topic (see further down the page). Whether you use a framework or not, the goal is to identify the main concepts of your question and the synonyms / similar terms that might be used to describe each of those concepts:
Image from UCSF Library: https://guides.ucsf.edu/c.php?g=126216&p=825824
It is not always necessary to include all of your main concepts in the search. In some PICO questions, the outcome (O) is implied and does not need to be included. In other cases, any and all outcomes might of interest and so the search strategy can leave this out to keep it open.
Example for the research question: In seniors with dementia, does a falls prevention program, compared to no falls prevention program, result in decreased falls?
Applying a framework when developing a question can help to identify the key concepts and determine inclusion and exclusion criteria.
PICo: | Population/Participants, phenomenon of Interest, Context |
Patient/Problem, Intervention, Comparison, Outcome, (Study design) |
|
PECO(S): |
Patient/Problem, Exposure, Comparison, Outcome, (Study design) |
PESICO: |
Person, Environment, Stakeholders, Intervention, Comparison, Outcome |
PIPOH: |
Population, Interventions, Professionals/Patients, Outcome, Healthcare Setting |
PS: | Population, Situation |
SPICE: | Setting, Perspectives, Intervention, Comparison, Evaluation |
P (Patient, Population, Problem) | I (Intervention) | C (Comparison) | O (Outcome) |
How would I describe a group of patients similar to mine? | What main interventions, prognostic factors or exposure are you considering? | What is the main alternative to compare with the intervention? | What can you hope to accomplish, measure, improve or effect? |
In: Otherwise healthy children… |
Does: exposure to in utero cocaine… |
Versus: children not exposed to in utero cocaine… |
Result in: increased risk of learning disabilities? |
In: Primary school children |
Does: school-based physical activity |
Versus: no school-based physical activity |
Result in: a decrease in obesity |
S (Setting) | P (Perspective) | I (Intervention) | C (Comparison) | E (Evaluation) |
Where? | For whom? | What? | Compared with what? | With what result? |
In the setting of rural communities | From the perspective of a pregnant woman | How does facility-based care | Compare with traditional birth attendants at home | In relation to the woman’s perceptions and experiences? |
Example from: Booth, A., Noyes, J., Flemming, K., Moore, G., Tunçalp, Ö., & Shakibazadeh, E. (2019). Formulating questions to explore complex interventions within qualitative evidence synthesis. BMJ Global Health, 4(Suppl 1), e001107.